synthases, also known as PKSs, are a family of enzyme complexes
that produce a large class of secondary metabolites known as polyketides
which possess pharmacologically important properties including antibiotic,
antifungal, antitumor and immunosuppressive activities. PKS includes
type I, II, and III(Austin and Noel, 2003). Among this, the type
III polyketide synthases are responsible for the synthesis of polyketides such as chalcone and
stilbene. In addition to the CHSs, the PKS super family also includes
functionally divergent members like 2-pyrone synthase, Phloroisovalerophenone
synthase, Trihydroxybenzophenone synthase, Acridone synthase, Stilbene
synthase, Pentaketide chromone synthase, Octaketide synthase, resveratrol
synthase, Benzalacetone synthase, Aloesone synthase and stilbenecarboxylate
synthase(Austin and Noel, 2003; Schroder, 1997).
III polyketide synthases are small homodimeric proteins of approximately
40- 45 kDa, and their derivatives possess chemopreventive activity
against certain diseases(Jang et al.,1997; Clement et al.,1998).
As the volume of polyketide data is increasing data by day, a platform
including all details will help the researchers to find out all
available data with out much time consumption.
Austin, M.B., and Noel, J.P. (2003). The chalcone
synthase superfamily of type III polyketide synthases. Nat. Prod.
Schröder, J. (1997). A family of plant-specific
polyketide synthases: facts and predictions. Trends in Plant Science
Clement, M.V., Hirpara, J.L., Chawdhury, S.H.
and Pervaiz, S. (1998). Chemopreventive Agent Resveratrol, a Natural
Product Derived From Grapes, Triggers CD95 Signaling-Dependent Apoptosis
in Human Tumor Cells. Blood, 92(3): 996-1002.
Jang, M., Cai, L., Udeani, G.O., Slowing, K.V.,
Thomas, C.F., Beecher, C.W., Fong, H.H., Farnsworth, N.R., Kinghorn,
A.D., Mehta, R.G., Moon, R.C. and Pezzuto, J.M. (1997). Cancer chemopreventive
activity of resveratrol, a natural product derived from grapes.
Science 275(5297): 218-220.